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BACKGROUND: Representative formulae of Qi-Benefiting and Blood-Activating Chinese medicinal herbs Bu Yang Huan Wu Tang (BYHWT) can improve microcirculation and hypoxia, decrease fibrinogen, resist platelet aggregation, reduce blood lipid, dilate blood vessel, resist thrombosis, and reduce neonatal plaque rupture, and has a multi-target, multi-channel anti-atherosclerotic effect. OBJECTIVE: To observe the influence of representative formulae of Qi-Benefiting and Blood-Activating Chinese medicinal herbs BYHWT on aorta Rho kinase, tissue factor, matrix metal oproteinase-2, matrix metal oproteinase-9 mRNA expression in atherosclerosis models, and to explore the action mechanism of BYHWT on anti-atherosclerosis. METHODS: Vitamin D3 and high fat diet induced atherosclerosis in rats. 60 rats were randomly divided into normal control group, model group, 10 g/kg BYHWT therapy group, 20 g/kg BYHWT therapy group, simvastatin control group and BYHWT prevention group (n=10). At 28 days after model establishment, the expression level of Rho kinase, tissue factor, matrix metal oproteinase-2, matrix metal oproteinase-9 mRNA expression and blood lipid level were detected. RESULTS AND CONCLUSION: (1) High fat diet and vitamin D3 could induce atherosclerosis in rats. Atherosclerotic plaque formed in the model group. (2) Rho kinase, tissue factor, matrix metal oproteinase-2, matrix metal oproteinase-9 mRNA expression and blood lipid were significantly lower in the normal control group, 20 g/kg BYHWT therapy group, simvastatin control group and BYHWT prevention group than in the model group (P 0.05). (3) Results indicated that Qi-Benefiting and Blood-Activating BYHWT can resist atherosclerosis, down-regulate the expression of Rho kinase, tissue factor, matrix metal oproteinase-2, and matrix metal oproteinase-9 mRNA expression, which may be one of the mechanisms of anti-atherosclerosis.
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OBJECTIVE To investigate the impact of disinfection quality in surgical dressing room on the healing of wound with dressing exchanges in order to implement procedures to prevent nosocomial infection. METHODS A retrospective investigation was performed and cases of poor surgical wound healing from Jan 2006 to Dec 2007 were collected and analised. Effective measures were taken to enhance the management and surveillance in the dressing room. RESULTS After taking the prevention procedure,the passing rate of disinfection was increased. Before implementing the prevention procedure the passing rates of air,surface and finger cultured were 83.3%,83.3% and 75.0%,respectively,After taking the prevention procedure the passing rates of above were all 100.0%.The rate of poor wound healing decreased from 4.16% to 1.59%. CONCLUSIONS The disinfection quality of dressing room has direct effects on the wound healing. The management of dressing room disinfection should be emphasized to cut down the nosocomial infections of wound.
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OBJECTIVE To monitor the hand contamination after dressing change for the infected wound and to explore an effective way for hand hygiene. METHODS Caregivers were divided into three groups after applying dressing on infected wound:group 1(no hand-washing),group 2(regular hand-washing),and group 3(standard hand-washing),the pathogens in hands were monitored and the effects of two ways of hand-washing were compared. RESULTS The rate of hand-carrying pathogens after dressing change for the infected wound was 100.0%,the qualified rate of regular hand-washing was only 47.9% and that of standard hand-washing (six-steps method)was 97.9%. CONCLUSIONS The standard hand-washing is more effective than regular hand-washing. Correct hand hygiene should be emphasized to prevent and control nosocomial infection.
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OBJECTIVE To detect the effect of AcasinTM dressing on surgical incision healing.METHODS Eighty cases with types Ⅰand Ⅱsurgical incision operation at outpatient clinic were divided into study group and control group.AcasinTM dressing was applied to study group while common aseptic dressing was applied to control group.The bacterial test results and the healing condition of the incision were observed.RESULTS The bacterial tests were negative in study group,the average healing time was 7.32?1.74 days,the healed rate of stage Ⅰ was 100.00%.The bacterial tests were positive in 10 cases of control group,10 cases had redness in incision,5 cases with drainage leakage,the average healing time was 10.12?2.24 days,The healed rate of stage Ⅰ was 90.00%.CONCLUSIONS AcasinTM dressing can eridicate pathogenic organism in surgical incision and suture,It can effectively prevent incision infection,and promote stage Ⅰincision healing.It is worth spread in clinic.